IL-10 is an autocrine inhibitor of human placental cytotrophoblast MMP-9 production and invasion.

@article{Roth1999IL10IA,
  title={IL-10 is an autocrine inhibitor of human placental cytotrophoblast MMP-9 production and invasion.},
  author={Ioana Roth and Susan J. Fisher},
  journal={Developmental biology},
  year={1999},
  volume={205 1},
  pages={194-204}
}
During human placentation, fetal cytotrophoblast stem cells differentiate and then invade the uterine wall and its associated spiral arteries. This process anchors the placenta to the uterus and supplies maternal blood to the fetus. Cytotrophoblast invasion in vitro requires the expression of matrix metalloproteinase-9 (MMP-9). Recently, we showed that cytotrophoblasts produce interleukin-10 (IL-10), a potent immunomodulatory cytokine that could have paracrine effects on the maternal immune… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Similar Papers

Loading similar papers…