IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells.

@article{Choe1998IL10IM,
  title={IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells.},
  author={Jongseon Choe and Yong Sung Choi},
  journal={European journal of immunology},
  year={1998},
  volume={28 2},
  pages={508-15}
}
Germinal center (GC) B cells undergo proliferation, somatic hypermutation and isotype switching in the course of differentiation into plasma cells to produce high-affinity antibodies. To understand the molecular mechanism regulating the expansion of memory B cells and the termination of expansion by differentiation into plasma cells, we investigated the effect of interleukin-2 (IL-2), IL-4, IL-10 and CD40 ligand (CD40L) on the differentiation of GC B cells in the defined culture system… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 33 references

Contact-mediated monocyte IL-10 induction

S. L. Parry, M. Sebbag, M. Feldmann, F. M. Brennan
J. Immunol • 1997

Different activation requirements for naive and memory B cells

V. Kindler, R. H. Zubler
J. Immunol • 1997

Memory B cell generation by IL-4 and BCR stimulation

J. Choe, Kim, H.-S, R. J. Armitage, Y. S. Choi
J. Immunol • 1997

Differentiation and apoptosis of germinal center B cells

J. Choe, Kim, +3 authors Y. S. Choi
J. Immunol • 1996

Human memory Ab responses are CD 40 independent

A. Silvy, C. Lagresle, C. Bella, T. Defrance
Eur . J . Immunol . • 1996

Human memory Ab responses are CD40

A. Silvy, C. Lagresle, C. Bella, T. Defrance
independent. Eur. J. Immunol • 1996

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