IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells.

@article{Woszczek2008IL10IC,
  title={IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells.},
  author={Grzegorz Woszczek and L Chen and Sahrudaya Nagineni and James H. Shelhamer},
  journal={Journal of immunology},
  year={2008},
  volume={180 11},
  pages={7597-603}
}
The immunoregulatory cytokine IL-10 plays an essential role in down-modulating adaptive and innate immune responses leading to chronic inflammatory diseases. In contrast, cysteinyl leukotrienes (cysLTs), important proinflammatory mediators of cell trafficking and innate immune responses, are thought to enhance immune reactions in the pathogenesis of diseases, such as bronchial asthma, atherosclerosis, and pulmonary fibrosis. The aim of this study was to determine the IL-10 regulatory role in… CONTINUE READING

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