IL-10 encoded by viruses: a remarkable example of independent acquisition of a cellular gene by viruses and its subsequent evolution in the viral genome.

@article{Ouyang2014IL10EB,
  title={IL-10 encoded by viruses: a remarkable example of independent acquisition of a cellular gene by viruses and its subsequent evolution in the viral genome.},
  author={Ping Kai Ouyang and Krzysztof L Rakus and Steven J. van Beurden and Adrie H. Westphal and Andrew J. Davison and Derek Gatherer and Alain F C Vanderplasschen},
  journal={The Journal of general virology},
  year={2014},
  volume={95 Pt 2},
  pages={
          245-62
        }
}
Many viruses have evolved strategies to deregulate the host immune system. These strategies include mechanisms to subvert or recruit the host cytokine network. IL-10 is a pleiotropic cytokine that has both immunostimulatory and immunosuppressive properties. However, its key features relate mainly to its capacity to exert potent immunosuppressive effects. Several viruses have been shown to upregulate the expression of cellular IL-10 (cIL-10) with, in some cases, enhancement of infection by… CONTINUE READING

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