IL-10 delivery by AAV5 vector attenuates inflammation in mice with pseudomonas pneumonia

@article{Buff2010IL10DB,
  title={IL-10 delivery by AAV5 vector attenuates inflammation in mice with pseudomonas pneumonia},
  author={Scotty M Buff and Hsin-Hao Yu and John N. McCall and Sylvia McGeary Caldwell and Thomas Ferkol and Terence R. Flotte and Isabel Virella-Lowell},
  journal={Gene Therapy},
  year={2010},
  volume={17},
  pages={567-576}
}
Lung infections with Pseudomonas aeruginosa and other pathogens in cystic fibrosis (CF) cause progressive airway obstruction and tissue damage, the predominant cause of morbidity and mortality in CF. We investigated whether a recombinant adeno-associated virus type 5 (AAV5) vector expressing murine interleukin (IL)-10 (AAV5.Cβ-mIL-10), a regulatory/anti-inflammatory cytokine, could decrease airway inflammation in IL-10 knockout mice chronically infected with mucoid P. aeruginosa. Mice that… CONTINUE READING