IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance.

@article{Sewnath2001IL10deficientMD,
  title={IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance.},
  author={Miguel E. Sewnath and Dariusz Piotr Olszyna and Rakesh S. Birjmohun and Fibo Jan ten Kate and Dirk. J. Gouma and Tom van der Poll},
  journal={Journal of immunology},
  year={2001},
  volume={166 10},
  pages={6323-31}
}
To determine the role of endogenous IL-10 in local antibacterial host defense and in the development of a systemic inflammatory response syndrome during abdominal sepsis, IL-10 gene-deficient (IL-10(-/-)) and wild-type (IL-10(+/+)) mice received an i.p. injection with Escherichia coli. Peritonitis was associated with a bacterial dose-dependent increase in IL-10 concentrations in peritoneal fluid and plasma. The recovery of E. coli from the peritoneal fluid, blood, and lungs was diminished in IL… CONTINUE READING
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