IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection.

@article{Guilliams2009IL10DT,
  title={IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection.},
  author={Martin Guilliams and Kiavash Movahedi and Tom Bosschaerts and Thierry Vandendriessche and Marinee Khim Chuah and Michel H{\'e}rin and Abel Acosta-Sanchez and Ling Ma and M. G. Moser and Jo A. van Ginderachter and Lea Brys and Patrick de Baetselier and Alain Beschin},
  journal={Journal of immunology},
  year={2009},
  volume={182 2},
  pages={1107-18}
}
Antiparasite responses are associated with the recruitment of monocytes that differentiate to macrophages and dendritic cells at the site of infection. Although classically activated monocytic cells are assumed to be the major source of TNF and NO during Trypanosoma brucei brucei infection, their cellular origin remains unclear. In this study, we show that bone marrow-derived monocytes accumulate and differentiate to TNF/inducible NO synthase-producing dendritic cells (TIP-DCs) in the spleen… CONTINUE READING