IL-10 controls dendritic cell-induced T-cell reactivation in the skin to limit contact hypersensitivity.

@article{GirardMadoux2012IL10CD,
  title={IL-10 controls dendritic cell-induced T-cell reactivation in the skin to limit contact hypersensitivity.},
  author={Mathilde J. H. Girard-Madoux and Junda M. Kel and Boris Reizis and Bj{\"o}rn E Clausen},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={129 1},
  pages={143-50.e1-10}
}
BACKGROUND IL-10 is a pleiotropic cytokine and potent negative regulator of both innate and adaptive immune responses. Consequently, IL-10-deficient (IL-10(-/-)) mice have enhanced contact hypersensitivity (CHS) to topical hapten. OBJECTIVE Although the importance of IL-10 production by (regulatory) T cells and Langerhans cells in regulating CHS has been established by cell type-specific il-10 gene targeting, it remains elusive to what extent IL-10 controls dendritic cell (DC) function in… CONTINUE READING
19 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…