IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

Abstract

AIM To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-alpha and the interleukin (IL)-10 in childhood Crohn's disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes. METHODS Ten variants… (More)

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