IL-10 alters prolactin receptor activity emulating that during breast cancer.

@article{Paul2010IL10AP,
  title={IL-10 alters prolactin receptor activity emulating that during breast cancer.},
  author={Sonali Paul and Amlan Biswas and Krittika Sasmal and Subhadeep Mukherjee and Tapas Kr. Biswas and Ratna Biswas},
  journal={Cytokine},
  year={2010},
  volume={51 2},
  pages={144-50}
}
Peripheral blood mononuclear cells (PBMC) of breast cancer patients show altered prolactin (PRL)-induced proinflammatory response and express short form of prolactin receptor (PRL-R), besides secreting elevated level of interleukin (IL)-10 than that of the normal counterparts. IL-10 depleted the functional long form of PRL-R mRNA and protein, expressed PRL-R (SF) mRNA and blocked the PRL response found in normal individuals, which could be a mechanism to suppress the proinflammatory immune… CONTINUE READING

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