IL-10 Suppression of NK/DC Crosstalk Leads to Poor Priming of MCMV-Specific CD4 T Cells and Prolonged MCMV Persistence

@inproceedings{Mandari2012IL10SO,
  title={IL-10 Suppression of NK/DC Crosstalk Leads to Poor Priming of MCMV-Specific CD4 T Cells and Prolonged MCMV Persistence},
  author={Sanja Mandari{\'c} and Senta Maria Walton and Thomas R{\"u}licke and Kirsten Richter and Mathilde J. H. Girard-Madoux and Bj{\"o}rn E Clausen and Antonija Zurunic and Masahito Kamanaka and Richard A Flavell and Stipan Jonji{\'c} and Annette Oxenius},
  booktitle={PLoS pathogens},
  year={2012}
}
IL-10 is an anti-inflammatory cytokine that regulates the extent of host immunity to infection by exerting suppressive effects on different cell types. Herpes viruses induce IL-10 to modulate the virus-host balance towards their own benefit, resulting in prolonged virus persistence. To define the cellular and molecular players involved in IL-10 modulation of herpes virus-specific immunity, we studied mouse cytomegalovirus (MCMV) infection. Here we demonstrate that IL-10 specifically curtails… CONTINUE READING

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