IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.

@article{Hsu2015IL10PD,
  title={IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.},
  author={Peter S Hsu and Brigitte Santner-Nanan and Mingjing Hu and Kristen K. Skarratt and Cheng Hiang Lee and Michael O. Stormon and Melanie Wong and Stephen J. Fuller and Ralph Kay Heinrich Nanan},
  journal={Journal of immunology},
  year={2015},
  volume={195 8},
  pages={3665-74}
}
Foxp3(+) regulatory T cells (Tregs) play essential roles in maintaining the immune balance. Although the majority of Tregs are formed in the thymus, increasing evidence suggests that induced Tregs (iTregs) may be generated in the periphery from naive cells. However, unlike in the murine system, significant controversy exists regarding the suppressive capacity of these iTregs in humans, especially those generated in vitro in the presence of TGF-β. Although it is well known that IL-10 is an… CONTINUE READING
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