IL-10: the master regulator of immunity to infection.

@article{Couper2008IL10TM,
  title={IL-10: the master regulator of immunity to infection.},
  author={Kevin N Couper and Daniel G. Blount and Eleanor M. Riley},
  journal={Journal of immunology},
  year={2008},
  volume={180 9},
  pages={5771-7}
}
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage. In consequence, IL-10 can both impede pathogen clearance and ameliorate immunopathology. Many different types of cells can produce IL-10, with the major source of IL-10 varying in different tissues or during acute or chronic stages of the same infection. The priming of these… CONTINUE READING
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