IL-10: An "immunologic scalpel" for atherosclerosis?

  title={IL-10: An "immunologic scalpel" for atherosclerosis?},
  author={Robert A. Terkeltaub},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={19 12},
Mononuclear leukocyte–mediated inflammation is a central feature of atherosclerosis. Using measures that diminish lesion monocyte recruitment and macrophage-mediated inflammation, investigators have shown these specific events to be essential to the development and progression of atherosclerotic lesions. Lesion T lymphocytes have an activated phenotype and colocalize with lesion macrophages, particularly in early disease. However, the role of lesion T lymphocytes in atherogenesis is not as well… CONTINUE READING

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