IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

  title={IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.},
  author={Jennifer L. Swantek and May F. Tsen and Melanie H Cobb and James A Thomas},
  journal={Journal of immunology},
  volume={164 8},
Endotoxin triggers many of the inflammatory, hemodynamic, and hematological derangements of Gram-negative septic shock. Recent genetic studies in mice have identified the Toll-like receptor 4 as the transmembrane endotoxin signal transducer. The IL-1 intracellular signaling pathway has been implicated in Toll-like receptor signal transduction. LPS-induced activation of the IL-1 receptor-associated kinase (IRAK), and the influence of IRAK on intracellular signaling and cellular responses to… CONTINUE READING

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