IL-1 beta induces proMMP-9 expression via c-Src-dependent PDGFR/PI3K/Akt/p300 cascade in rat brain astrocytes.

@article{Wu2008IL1BI,
  title={IL-1 beta induces proMMP-9 expression via c-Src-dependent PDGFR/PI3K/Akt/p300 cascade in rat brain astrocytes.},
  author={Cheng-Ying Wu and Hsi-Lung Hsieh and Chi-Chin Sun and C P Tseng and Chuen-Mao Yang},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 4},
  pages={1499-512}
}
In a previous study, interleukin-1beta (IL-1beta) has been shown to induce matrix metalloproteinases (MMPs) expression through mitogen-activated protein kinases and nuclear factor-kappaB pathways in rat brain astrocytes. Moreover, transactivation of growth factor receptors and phosphatidylinositol 3-kinase (PI3K)/Akt cascade has been mentioned in the expression of several inflammatory genes. Here, we first report that IL-1beta-induced up-regulation of proMMP-9 was inhibited by genistein. IL… CONTINUE READING

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