IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

  title={IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.},
  author={Brendan John O'Sullivan and Helen E. Thomas and Saparna Pai and Pere Santamaria and Yoichiro Iwakura and Raymond J Steptoe and Thomas W. H. Kay and Ranjeny Thomas},
  journal={Journal of immunology},
  volume={176 12},
IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile inflammatory arthritis, diseases with mutations in the NALP/cryopyrin complex and Crohn's disease, and is genetically or clinically associated with many others. IL-1 is a pleiotropic proinflammatory cytokine; however the mechanisms by which increased IL-1 signaling promotes autoreactive T cell activity are not clear. Here we show that autoimmune-prone NOD and IL-1 receptor antagonist-deficient C57BL/6 mice… CONTINUE READING
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