IL-1 activates two phospholipid signaling pathways in intestinal epithelial cells

@article{Homaidan2001IL1AT,
  title={IL-1 activates two phospholipid signaling pathways in intestinal epithelial cells},
  author={FadiaR. Homaidan and Iman Chakroun and Ghassan S. Dbaibo and Wissal El-Assaad and Marwan Eid El-Sabban},
  journal={Inflammation Research},
  year={2001},
  volume={50},
  pages={375-381}
}
Objective and Design: the aim of the study was to decipher the molecular signals involved in IL-1's action on intestinal epithelial cells (IEC).¶Materials and Methods: Mode-K cells, used as a model of IEC, were treated with IL-1, and PLA2 activity and PGE2, ceramide, and cyclooxygenase-2 (COX-2) levels were measured using enzyme-immuno-assay kit, EIA, thin-layer chromatography and western blotting assays respectively.¶Results: IL-1 caused a concentration- and time-dependent increase in PLA2… CONTINUE READING
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