IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 Cells.

@article{Park2015IL1RB,
  title={IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 Cells.},
  author={Min-Jung Park and Seung Hoon Lee and Sung-Hee Lee and Eun-jung Lee and Eun-Kyung Kim and Jong Young Choi and Mi-La Cho},
  journal={Mediators of inflammation},
  year={2015},
  volume={2015},
  pages={631384}
}
T helper (Th) 17 cells are a subset of Th cells expressing interleukin- (IL-) 17 and initiating an inflammatory response in autoimmune diseases. Graft-versus-host disease (GVHD) is an immune inflammatory disease caused by interactions between the adaptive immunity of donor and recipient. The Th17 lineage exhibits proinflammatory activity and is believed to be a central player in GVHD. IL-1 performs a key function in immune responses and induces development of Th17 cells. Here, we show that… CONTINUE READING