IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex

  title={IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex},
  author={Alissa A. Chackerian and Elizabeth R. Oldham and Erin E. Murphy and Jochen Schmitz and Stefan Pflanz and Robert A. Kastelein},
  journal={The Journal of Immunology},
  pages={2551 - 2555}
IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune response. IL-33 mediates signal transduction through ST2, a receptor expressed on Th2 and mast cells. In this study, we demonstrate that IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex. Additionally, IL-1RAcP is required for IL-33… 

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