IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.

@article{Jayaraman2013IL1PA,
  title={IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.},
  author={Pushpa Jayaraman and Isabel Sada-Ovalle and Tomoyasu Nishimura and Ana Carrizossa Anderson and Vijay K Kuchroo and Heinz G. Remold and Samuel M Behar},
  journal={Journal of immunology},
  year={2013},
  volume={190 8},
  pages={4196-204}
}
In vivo control of Mycobacterium tuberculosis reflects the balance between host immunity and bacterial evasion strategies. Effector Th1 cells that mediate protective immunity by depriving the bacterium of its intracellular niche are regulated to prevent overexuberant inflammation. One key immunoregulatory molecule is Tim3. Although Tim3 is generally recognized to downregulate Th1 responses, we recently described that its interaction with Galectin-9 expressed by M. tuberculosis-infected… CONTINUE READING

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