IL-1β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease.

@article{Pathak2011IL1IO,
  title={IL-1β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease.},
  author={Shresh Pathak and Elliot Goldofsky and Esther X Vivas and Vincent R Bonagura and Andrea Vambutas},
  journal={Journal of immunology},
  year={2011},
  volume={186 3},
  pages={1870-9}
}
Autoimmune inner ear disease is an enigmatic disorder characterized by recurring episodes of sudden or progressive sensorineural hearing loss. Hearing loss can be improved by timely corticosteroid administration, but only half of those treated respond, and for many responders, that response is lost over time. The mechanisms that control corticosteroid responsiveness in this disorder are largely uncharacterized. We have previously identified that the induction by dexamethasone of IL-1R type II… CONTINUE READING

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