IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle

@inproceedings{Indalao2016IL1IA,
  title={IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle},
  author={Irene L. Indalao and Takako Sawabuchi and Etsuhisa Takahashi and Hiroshi Kido},
  booktitle={Archives of Virology},
  year={2016}
}
Severe influenza is characterized by a cytokine storm, and the influenza virus–cytokine–trypsin cycle is one of the important mechanisms of viral multiplication and multiple organ failure. The aim of this study was to define the key cytokine(s) responsible for trypsin upregulation. Mice were infected with influenza virus strain A/Puerto Rico/8/34 (H1N1) or treated individually or with a combination of interleukin-1β, interleukin-6, and tumor necrosis factor α. The levels of these cytokines and… CONTINUE READING