IL-1β augments H2S-induced increase in intracellular Ca2+ through polysulfides generated from H2S/NO interaction.

@article{Ujike2018IL1AH,
  title={IL-1β augments H2S-induced increase in intracellular Ca2+ through polysulfides generated from H2S/NO interaction.},
  author={Ayako Ujike and Tomoki Kuraishi and Soichiro Yamaguchi and Ryota Eguchi and Taisuke Kitano and Jumpei Kamise and Hiroshi Ito and Ken-Ichi Otsuguro},
  journal={European journal of pharmacology},
  year={2018},
  volume={821},
  pages={
          88-96
        }
}
H2S has excitatory and inhibitory effects on Ca2+ signals via transient receptor potential ankyrin 1 (TRPA1) and ATP-sensitive K+ channels, respectively. H2S converts intracellularly to polysulfides, which are more potent agonists for TRPA1 than H2S. Under inflammatory conditions, changes in the expression and activity of these H2S target channels and/or the conversion of H2S to polysulfides may modulate H2S effects. Effects of proinflammatory cytokines on H2S-induced Ca2+ signals and… CONTINUE READING
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