IL-1β and TGF-β act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells.

@article{Hebel2011IL1AT,
  title={IL-1β and TGF-β act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells.},
  author={Katrin Hebel and Marion Rudolph and Bernhard Kosak and Hyun-Dong Chang and Jana Butzmann and Monika C Brunner-Weinzierl},
  journal={Journal of immunology},
  year={2011},
  volume={187 11},
  pages={
          5627-35
        }
}
Cytokines are critical messengers that control the differentiation of Th cells. To evaluate their impact on the fate of human naive CD4(+) T cells from cord and adult blood, early T cell differentiation was monitored after T cell activation in the presence of pro- and anti-inflammatory cytokines. Interestingly, the analysis of Th cell lineage-specific molecules revealed that IL-1β on its own mediates differentiation of Th cells that secrete a wide range of proinflammatory cytokines and stably… CONTINUE READING
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