IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

@inproceedings{Negash2013IL1PT,
  title={IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease},
  author={Amina A. Negash and Hilario J. Ramos and Nanette Crochet and Daryl T. Y. Lau and Brian P Doehle and Neven Papic and Don A. Delker and Juandy Jo and Antonio Bertoletti and Curt H. Hagedorn and Michael Gale},
  booktitle={PLoS pathogens},
  year={2013}
}
Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer but the processes that promote hepatic inflammation by HCV are not defined. We provide a systems biology analysis with multiple lines of evidence to indicate that interleukin-1β (IL-1β) production by intrahepatic macrophages confers liver inflammation through HCV-induced inflammasome signaling. Chronic hepatitis C patients exhibited… CONTINUE READING
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