IL-1β AND TNF-α, BUT NOT IFN-α, IFN-γ, IL-6 OR IL-8, ARE SECRETORY MEDIATORS IN HUMAN DISTAL COLON

@inproceedings{Bode1998IL1AT,
  title={IL-1β AND TNF-α, BUT NOT IFN-α, IFN-γ, IL-6 OR IL-8, ARE SECRETORY MEDIATORS IN HUMAN DISTAL COLON},
  author={Hagen Bode and Heinz Schmitz and Michael Fromm and Peter Scholz and E. O. Riecken and J{\"o}rg-Dieter Schulzke},
  year={1998}
}
Abstract Inflammatory bowel disease (IBD) and HIV infection can cause diarrhoea which is accompanied by elevated cytokine levels. To elucidate a pathogenic role of cytokines, their effect on ion secretion was studied in human distal colon using the Ussing technique. Interluekin 1β (IL-1β) dose dependently increased short-circuit current (I SC ). An I SC maximum of 2.5±0.3 μmol.h −1 .cm −2 was reached at 20 ng/ml within 43±4 min. 22 Na + and 36 Cl − fluxes were not altered and residual flux… CONTINUE READING

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