IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

@article{Bal2016IL1IA,
  title={IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs},
  author={Suzanne M Bal and Jochem H. Bernink and Maho Nagasawa and Jelle Groot and Medya Mara Shikhagaie and Kornel Golebski and Cornelis M van Drunen and Ren{\'e} Lutter and Ren{\'e} E. Jonkers and Pleun Hombrink and M{\'e}lanie Bruchard and Julien Villaudy and J. Marius Munneke and Wytske F Fokkens and Jonas S Erjef{\"a}lt and Hergen Spits and Xavier Romero Ros},
  journal={Nature Immunology},
  year={2016},
  volume={17},
  pages={636-645}
}
Group 2 innate lymphoid cells (ILC2s) secrete type 2 cytokines, which protect against parasites but can also contribute to a variety of inflammatory airway diseases. We report here that interleukin 1β (IL-1β) directly activated human ILC2s and that IL-12 induced the conversion of these activated ILC2s into interferon-γ (IFN-γ)-producing ILC1s, which was reversed by IL-4. The plasticity of ILCs was manifested in diseased tissues of patients with severe chronic obstructive pulmonary disease (COPD… CONTINUE READING
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References

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Showing 1-10 of 46 references

Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis : a randomized clinical trial

  • S. Wenzel
  • J . Am . Med . Assoc .
  • 2016

Inflammatory triggers associated with COPD exacerbations orchestrate ILC 2 plasticity in the lung

  • P. J. Barnes
  • Nat . Immunol .
  • 2016

Interleukin - 33 and interferon - γ counter - regulate group 2 innate lymphoid cell activation during immune perturbation

  • J. C. Nussbaum
  • Immunity
  • 2015

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