IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

@article{Bal2016IL1IA,
  title={IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs},
  author={S. Bal and J. Bernink and M. Nagasawa and Jelle Groot and M. Shikhagaie and K. Golebski and C. Drunen and R. Lutter and R. Jonkers and P. Hombrink and M. Bruchard and Julien Villaudy and J. Munneke and W. Fokkens and J. Erjef{\"a}lt and H. Spits and X. Ros},
  journal={Nature Immunology},
  year={2016},
  volume={17},
  pages={636-645}
}
  • S. Bal, J. Bernink, +14 authors X. Ros
  • Published 2016
  • Medicine, Biology
  • Nature Immunology
  • Group 2 innate lymphoid cells (ILC2s) secrete type 2 cytokines, which protect against parasites but can also contribute to a variety of inflammatory airway diseases. We report here that interleukin 1β (IL-1β) directly activated human ILC2s and that IL-12 induced the conversion of these activated ILC2s into interferon-γ (IFN-γ)-producing ILC1s, which was reversed by IL-4. The plasticity of ILCs was manifested in diseased tissues of patients with severe chronic obstructive pulmonary disease (COPD… CONTINUE READING

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