IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.

@article{Jorgensen2016IL1IA,
  title={IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.},
  author={Ine Jorgensen and J. M Padilla Lopez and Stefan A Laufer and Edward A Miao},
  journal={European journal of immunology},
  year={2016},
  volume={46 12},
  pages={
          2761-2766
        }
}
Inflammasomes activate caspase-1, initiating a lytic form of programmed cell death termed pyroptosis, which is an important innate immune defense mechanism against intracellular infections. We recently demonstrated in a mouse infection model of pyroptosis that instead of releasing bacteria into the extracellular space, bacteria remain trapped within the pyroptotic cell corpse, termed the pore-induced intracellular trap (PIT). This trapping mediates efferocytosis of the PIT and associated… CONTINUE READING
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