IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.

@article{Huaux2015IL1IC,
  title={IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.},
  author={François Huaux and Sandra Lo Re and Giulia Giordano and Francine Uwambayinema and Raynal Devosse and Yousof Yakoub and Nadtha Panin and Mihaly Palmai-Pallag and Virginie Rabolli and Monique A. Delos and Etienne Marbaix and Nicolas Dauguet and Isabelle Couillin and Bernhard Ryffel and Jean-Christophe Renauld and Dominique Lison},
  journal={The Journal of pathology},
  year={2015},
  volume={235 5},
  pages={698-709}
}
Macrophages play a central role in immune and tissue responses of granulomatous lung diseases induced by pathogens and foreign bodies. Circulating monocytes are generally viewed as central precursors of these tissue effector macrophages. Here, we provide evidence that granulomas derive from alveolar macrophages serving as a local reservoir for the expansion… CONTINUE READING