IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

@inproceedings{Botelho2011IL1IL1R1EI,
  title={IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice},
  author={Fernando M. Botelho and Carla M. T. Bauer and Donna K. Finch and Jake K. Nikota and Caleb C. J. Zavitz and Ashling Kelly and Kristen N. Lambert and Si{\^a}n C. Piper and Martyn L. Foster and James J. P. Goldring and Jadwiga A Wedzicha and Jennifer L Bassett and Jonathan L Bramson and Yoichiro Iwakura and Matthew A Sleeman and Roland Kolbeck and Anthony J Coyle and Alison A. Humbles and Martin R. St{\"a}mpfli},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood. METHODOLOGY AND PRINCIPAL FINDINGS The objective of this study was to assess IL-1 α and β expression in COPD patients and to investigate their respective roles in perpetuating cigarette smoke-induced… CONTINUE READING