IL-1\(\beta\) Is Upregulated in the Diabetic Retina and Retinal Vessels: Cell-Specific Effect of High Glucose and IL-1\(\beta\) Autostimulation

Abstract

Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1b-driven neuroinflammation in the pathogenesis of diabetic retinopathy. IL-1b is well known for its role in the induction and, through autostimulation, amplification of neuroinflammation. Upregulation of IL-1b has been consistently detected in the diabetic… (More)

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