IL-1, IL-18, and IL-33 families of cytokines.

  title={IL-1, IL-18, and IL-33 families of cytokines.},
  author={William P. Arend and Gaby Palmer and Cem Gabay},
  journal={Immunological reviews},
SUMMARY The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. All three cytokines are synthesized as precursor molecules and cleaved by the enzyme caspase-1 before or during release from the cell. The NALP-3 inflammasome is of crucial importance in generating active caspase-1. The IL-1 family contains two agonists, IL-1alpha and IL-1beta, a specific inhibitor, IL-1 receptor antagonist… CONTINUE READING
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IL-33 induces IL-13 produc- tion by mouse mast cells independently of IgE-FceRI signals

  • LH Ho
  • J Leukoc Biol
  • 2007
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