IL‐33 is secreted by psoriatic keratinocytes and induces pro‐inflammatory cytokines via keratinocyte and mast cell activation

@article{Balato2012IL33IS,
  title={IL‐33 is secreted by psoriatic keratinocytes and induces pro‐inflammatory cytokines via keratinocyte and mast cell activation},
  author={A. Balato and S. Lembo and M. Mattii and M. Schiattarella and R. Marino and Amato Paulis and N. Balato and F. Ayala},
  journal={Experimental Dermatology},
  year={2012},
  volume={21}
}
  • A. Balato, S. Lembo, +5 authors F. Ayala
  • Published 2012
  • Biology, Medicine
  • Experimental Dermatology
  • IL‐33 is a novel pro‐inflammatory cytokine and ligand for the orphan receptor ST2. Although originally defined as an inducer of Th2‐mediated responses, IL‐33 was recently found to be involved in arthritis, a Th1/Th17‐mediated disease. Here, we assessed the ability of IL‐33 to promote inflammation via mast cells (MCs) and keratinocytes (KCs) activation in psoriasis. IL‐33 resulted elevated in the skin but not in the serum of psoriasis patients. IL‐33 was secreted by psoriasis KCs and HaCaT cells… CONTINUE READING
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