IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.

Abstract

Control of NF-kappaB release through the inhibition of IKKbeta has been identified as a potential target for the treatment of inflammatory and autoimmune diseases. We have employed structure based virtual screening scheme to identify lead like molecule from ChemDiv database. Homology models of IKKbeta enzyme were developed based on the crystal structures of… (More)
DOI: 10.1016/j.bmc.2009.02.041

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