IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.

  title={IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.},
  author={Tom Luedde and Jan Heinrichsdorff and Rossana de Lorenzi and R De vos and Tania A Roskams and Manolis Pasparakis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 28},
Inflammatory destruction of intrahepatic bile ducts is a common cause of vanishing bile duct syndrome and cholestasis, often progressing to biliary cirrhosis and liver failure. However, the molecular mechanisms underlying the pathogenesis of inflammatory biliary disease are poorly understood. Here, we show that the two IkappaB kinases, IKK1/IKKalpha and IKK2/IKKbeta, display distinct collaborative and specific functions that are essential to protect the liver from cytokine toxicity and bile… CONTINUE READING
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