IKK mediates ischemia-induced neuronal death

@article{Herrmann2005IKKMI,
  title={IKK mediates ischemia-induced neuronal death},
  author={Oliver Herrmann and Bernd Baumann and Rossana de Lorenzi and Sajjad Muhammad and Wen Zhang and Jens Kleesiek and Maximillian V. Malfertheiner and Martin Köhrmann and Ioana Potrovita and Ira Maegele and Cordian Beyer and James R Burke and Mazahir T. Hasan and Hermann Prof. Dr. Bujard and Thomas Wirth and Manolis Pasparakis and Markus Schwaninger},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={1322-1329}
}
The IκB kinase complex IKK is a central component of the signaling cascade that controls NF-κB–dependent gene transcription. So far, its function in the brain is largely unknown. Here, we show that IKK is activated in a mouse model of stroke. To investigate the function of IKK in brain ischemia we generated mice that contain a targeted deletion of Ikbkb (which encodes IKK2) in mouse neurons and mice that express a dominant inhibitor of IKK in neurons. In both lines, inhibition of IKK activity… 
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This study demonstrates that physiological neuronal IKK/NF‐κB signaling is necessary and sufficient to protect neurons from trauma consequences and identifies elevated levels of the proapoptotic mediators Bax and Bad and enhanced expression of stress response genes.
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