IKK b is a b-catenin kinase that regulates mesenchymal stem cell differentiation

@inproceedings{Sui2018IKKBI,
  title={IKK b is a b-catenin kinase that regulates mesenchymal stem cell differentiation},
  author={Yipeng Sui and Zun Feng Liu and Se-Hyung Park and Sean Eric Thatcher and Beibei Zhu and J. P{\'e}rez-Alija Fernandez and Henrik Molina and Philip A Kern and Changcheng Zhou},
  year={2018}
}
Mesenchymal stem cells (MSCs) can give rise to both adipocytes and osteoblasts, but the molecular mechanisms underlying MSC fate determination remain poorly understood. IkB kinase b (IKKb), a central coordinator of inflammation and immune responses through activation of NF-kB, has been implicated as a critical molecular link between obesity and metabolic disorders. Here, we show that IKKb can reciprocally regulate adipocyte and osteoblast differentiation of murine and human MSCs through an NF… CONTINUE READING

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