IKK{beta} as a target for treatment of inflammation induced bone loss.

  title={IKK\{beta\} as a target for treatment of inflammation induced bone loss.},
  author={Maria Grazia Ruocco and Mickael Karin},
  journal={Annals of the rheumatic diseases},
  volume={64 Suppl 4},
The transcription factor nuclear factor (NF)-kappaB is well recognised as a pivotal player in osteoclastogenesis and inflammation induced bone loss. Here, the authors discuss their recent results, obtained using a genetic approach in mice, that indicate the importance of IKKbeta, and not IKKalpha, as a transducer of signals from receptor activator of NF-kappaB (RANK) to NF-kappaB. Ablation of IKKbeta results in lack of osteoclastogenesis and unresponsiveness of IKKbeta deficient mice to… CONTINUE READING
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