Corpus ID: 15397270

III Vasodilator Function Matter ? Cardiovascular Benefit of Cholesterol-Lowering Therapy : Does Improved Endothelial

  title={III Vasodilator Function Matter ? Cardiovascular Benefit of Cholesterol-Lowering Therapy : Does Improved Endothelial},
  author={R. Cannon},
Vasodilator Function Matter? Cardiovascular Benefit of Cholesterol-Lowering Therapy: Does Improved Endothelial Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.102.8.82 


The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion.
The improvement in endothelium-dependent vasomotion with cholesterol-lowering and antioxidant therapy may have important implications for the activity of myocardial ischemia and may explain in part the reduced incidence of adverse coronary events that is known to result from cholesterol- Lowering therapy. Expand
Effect of cholesterol-lowering therapy on coronary endothelial vasomotor function in patients with coronary artery disease.
The effects of cholesterol lowering on endothelial function are more complex than previously thought, and six months of cholesterol-lowering therapy has no significant effect on coronary endothelial vasomotor function in the study population of patients with coronary artery disease and mildly elevated cholesterol levels. Expand
Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease.
Cholesterol lowering with lovastatin significantly improved endothelium-mediated responses in the coronary arteries of patients with atherosclerosis, and improvement in the local regulation of coronary arterial tone could potentially relieve ischemic symptoms and signal the stabilization of the atherosclerotic plaque. Expand
Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients
Impairment of endothelium-dependent (acetylcholine-induced) dilation of the epicardial coronary arteries in hypercholesterolaemic patients with angiographically normal coronary arteries is thus reversible by reducing serum cholesterol. Expand
Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.
It is suggested that cholesterol-lowering therapy with pravastatin may improve endothelium-dependent coronary vasomotion, which may possibly contribute to the improvement of myocardial perfusion as well as the regression of coronary atherosclerosis. Expand
Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease.
Cholesterol lowering with lovastatin appears to be effective in eliminating myocardial ischemia during daily life in a significant proportion of patients. Expand
Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.
Exposure to coronary risk factors is associated with reduced resting and stimulated bioavailability of NO from the human coronary circulation, which contributes importantly to resting epicardial and coronary microvascular tone. Expand
Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and L-arginine.
  • A. Quyyumi
  • Medicine
  • Journal of the American College of Cardiology
  • 1998
Parenteral arginine produces non-stereo-specific peripheral vasodilation and improves endothelium-dependent vasodilated in patients with stable coronary artery disease by stimulation of insulin-dependent nitric oxide release or by nonenzymaticNitric oxide generation. Expand
Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators.
In low-risk patients with stable coronary artery disease, aggressive lipid-lowering therapy is at least as effective as angioplasty and usual care in reducing the incidence of ischemic events. Expand
Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries.
The preliminary findings suggest that the abnormal vascular response to acetylcholine may represent a defect in endothelial vasodilator function, and may be important in the pathogenesis of coronary vasospasm. Expand