Corpus ID: 15397270

III Vasodilator Function Matter ? Cardiovascular Benefit of Cholesterol-Lowering Therapy : Does Improved Endothelial

@inproceedings{Cannon2000IIIVF,
  title={III Vasodilator Function Matter ? Cardiovascular Benefit of Cholesterol-Lowering Therapy : Does Improved Endothelial},
  author={R. Cannon},
  year={2000}
}
Vasodilator Function Matter? Cardiovascular Benefit of Cholesterol-Lowering Therapy: Does Improved Endothelial Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.102.8.82 

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The improvement in endothelium-dependent vasomotion with cholesterol-lowering and antioxidant therapy may have important implications for the activity of myocardial ischemia and may explain in part the reduced incidence of adverse coronary events that is known to result from cholesterol- Lowering therapy. Expand
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TLDR
The effects of cholesterol lowering on endothelial function are more complex than previously thought, and six months of cholesterol-lowering therapy has no significant effect on coronary endothelial vasomotor function in the study population of patients with coronary artery disease and mildly elevated cholesterol levels. Expand
Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease.
TLDR
Cholesterol lowering with lovastatin significantly improved endothelium-mediated responses in the coronary arteries of patients with atherosclerosis, and improvement in the local regulation of coronary arterial tone could potentially relieve ischemic symptoms and signal the stabilization of the atherosclerotic plaque. Expand
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Impairment of endothelium-dependent (acetylcholine-induced) dilation of the epicardial coronary arteries in hypercholesterolaemic patients with angiographically normal coronary arteries is thus reversible by reducing serum cholesterol. Expand
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TLDR
It is suggested that cholesterol-lowering therapy with pravastatin may improve endothelium-dependent coronary vasomotion, which may possibly contribute to the improvement of myocardial perfusion as well as the regression of coronary atherosclerosis. Expand
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TLDR
Cholesterol lowering with lovastatin appears to be effective in eliminating myocardial ischemia during daily life in a significant proportion of patients. Expand
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TLDR
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In low-risk patients with stable coronary artery disease, aggressive lipid-lowering therapy is at least as effective as angioplasty and usual care in reducing the incidence of ischemic events. Expand
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The preliminary findings suggest that the abnormal vascular response to acetylcholine may represent a defect in endothelial vasodilator function, and may be important in the pathogenesis of coronary vasospasm. Expand
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