IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

  title={IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors},
  author={Valentina Evdokimova and Cristina E. Tognon and Tania Benatar and Wenyi Yang and Konstantin Krutikov and Michael N. Pollak and Poul H. Sorensen and Arun K. Seth},
  journal={Science Signaling},
  pages={ra92 - ra92}
By inactivating the insulin-like growth factor receptor, IGFBP7 suppresses growth and promotes cell death. Deadly Receptor Blockade When bound to insulin-like growth factor 1 or 2 (IGF-1/2), the IGF-1 receptor (IGF1R) promotes protein synthesis, cell growth, and survival. One mechanism by which the family of IGF-binding proteins (IGFBPs) interferes with IGF1R activation is by binding to IGF-1/2. Evdokimova et al. showed that, unlike other IGFBPs, IGFBP7 attenuated activation of IGF1R in various… 
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