IGFBP7: an oncosuppressor gene in thyroid carcinogenesis

@article{Vizioli2010IGFBP7AO,
  title={IGFBP7: an oncosuppressor gene in thyroid carcinogenesis},
  author={Maurizio Vizioli and Marialuisa Sensi and Claudia Janneth Linares Miranda and Loredana Cleris and Franca Formelli and Maria Chiara Anania and Marco Alessandro Pierotti and Angela Pontrandolfo Greco},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={3835-3844}
}
Insulin-like growth factor-binding protein 7 (IGFBP7) is a secreted protein involved in several cellular processes, including proliferation, senescence and apoptosis. Loss of IGFBP7 expression is a critical step in the development of human tumors, including melanoma and colon cancer. By microarray gene expression studies, we have detected downregulation of IGFBP7 gene expression in follicular and papillary thyroid tumors in comparison with normal thyroid tissue. Evaluation of publicly available… CONTINUE READING
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