IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma

  title={IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma},
  author={Amy L. Myers and Lin Lin and Derek J. Nancarrow and Zhuwen Wang and Daysha Ferrer-Torres and Dafydd Gareth Thomas and Mark B. Orringer and Jules Lin and Rishindra M. Reddy and David G Beer and Andrew C Chang},
Esophageal adenocarcinoma (EAC) patients commonly present with advanced stage disease and demonstrate resistance to therapy, with response rates below 40%. Understanding the molecular mechanisms of resistance is crucial for improvement of clinical outcomes. IGFBP2 is a member of the IGFBP family of proteins that has been reported to modulate both IGF and integrin signaling and is a mediator of cell growth, invasion and resistance in other tumor types. In this study, high IGFBP2 expression was… CONTINUE READING


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