IGFBP-4 and −5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells

@inproceedings{Crosley2014IGFBP4A,
  title={IGFBP-4 and −5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells},
  author={Erin J Crosley and Caroline E Dunk and Alexander G. Beristain and Julian K Christians},
  booktitle={Reproductive biology and endocrinology : RB&E},
  year={2014}
}
BACKGROUND Adverse gestational outcomes such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are associated with placental insufficiency. Normal placental development relies on the insulin-like growth factors -I and -II (IGF-I and -II), in part to stimulate trophoblast proliferation and extravillous trophoblast (EVT) migration. The insulin-like growth factor binding proteins (IGFBPs) modulate the bioavailability of IGFs in various ways, including sequestration, potentiation, and… CONTINUE READING