IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling.

@article{Kessler2013IGF2MB,
  title={IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling.},
  author={Sonja M Kessler and Juliane Pokorny and Vincent Zimmer and Stephan Laggai and Frank Lammert and Rainer Bohle and Alexandra K Kiemer},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2013},
  volume={304 4},
  pages={G328-36}
}
The insulin-like growth factor II (IGF2) mRNA binding protein (IMP) p62/IMP2-2, originally isolated from a hepatocellular carcinoma (HCC) patient, induces a steatotic phenotype when overexpressed in mouse livers. Still, p62 transgenic livers do not show liver cell damage but exhibit a pronounced induction of Igf2 and activation of the downstream survival kinase AKT. The aim of this study was to investigate the relation between p62 and IGF2 expression in the human system and to study potential… CONTINUE READING
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