IGF1R levels in the brain negatively correlate with longevity in 16 rodent species

@inproceedings{Azpurua2013IGF1RLI,
  title={IGF1R levels in the brain negatively correlate with longevity in 16 rodent species},
  author={Jorge Azpurua and Jiang-Nan Yang and Michael Van Meter and Zhengshan Liu and Julie Kim and Aliny A B Lobo Ladd and Ant{\^o}nio Augusto Coppi and Vera Gorbunova and Andrei Seluanov},
  booktitle={Aging},
  year={2013}
}
The insulin/insulin-like growth factor signaling (IIS) pathway is a major conserved regulator of aging. Nematode, fruit fly and mouse mutants with reduced IIS signaling exhibit extended lifespan. These mutants are often dwarfs leading to the idea that small body mass correlates with longevity within species. However, when different species are compared, larger animals are typically longer-lived. Hence, the role of IIS in the evolution of life history traits remains unresolved. Here we used… CONTINUE READING