IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter

@inproceedings{Mitchell2010IGF1AC,
  title={IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter},
  author={Geoffrey C. Mitchell and Jamia L Fillinger and Sivanandane Sittadjody and Jennifer L Avila and Randy Burd and Kirsten H. Limesand},
  booktitle={Cell Death and Disease},
  year={2010}
}
Radiotherapy for head and neck tumors often results in persistent loss of function in salivary glands. Patients suffering from impaired salivary function frequently terminate treatment prematurely because of reduced quality of life caused by malnutrition and other debilitating side-effects. It has been previously shown in mice expressing a constitutively active form of Akt (myr-Akt1), or in mice pretreated with IGF1, apoptosis is suppressed, which correlates with maintained salivary gland… CONTINUE READING

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