IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis.

@article{Xu2017IGF1IGF1RSTAT3SI,
  title={IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis.},
  author={Li Xu and Rui Zhou and Lezhong Yuan and Shiqing Wang and Xiaoyin Li and Huanrong Ma and Minyu Zhou and Changqie Pan and Jingwen Zhang and Na Ling Huang and Min Shi and Jianping Bin and Yulin Liao and Wangjun Liao},
  journal={Cancer letters},
  year={2017},
  volume={393},
  pages={76-85}
}
Interferon-induced transmembrane proteins (IFITMs) are expressed in some types of cancer. However, their precise roles in tumor progression remain unclear. The present study investigated the function of IFITM2 in gastric cancer (GC) progression. A retrospective analysis of a public database and 167 GC patients revealed that IFITM2 expression was upregulated in gastric tumor samples, which was positively correlated with disease progression, more frequent postoperative recurrence, and higher… CONTINUE READING
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