IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development.

@article{Li2011IGFSD,
  title={IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development.},
  author={Peng Li and Susana Cavallero and Ying Gu and Tim H-P Chen and Jennifer A. Hughes and Andrew Bassim Hassan and Jens C. Br{\"u}ning and Mohammad Pashmforoush and Henry M Sucov},
  journal={Development},
  year={2011},
  volume={138 9},
  pages={
          1795-805
        }
}
Secreted factors from the epicardium are believed to be important in directing heart ventricular cardiomyocyte proliferation and morphogenesis, although the specific factors involved have not been identified or characterized adequately. We found that IGF2 is the most prominent mitogen made by primary mouse embryonic epicardial cells and by a newly derived immortalized mouse embryonic epicardial cell line called MEC1. In vivo, Igf2 is expressed in the embryonic mouse epicardium during… CONTINUE READING

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