IGF binding proteins in cancer: mechanistic and clinical insights

@article{Baxter2014IGFBP,
  title={IGF binding proteins in cancer: mechanistic and clinical insights},
  author={Robert C. Baxter},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={329-341}
}
  • R. Baxter
  • Published 1 May 2014
  • Biology, Medicine
  • Nature Reviews Cancer
The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs) were originally characterized as passive reservoirs of circulating IGFs, but they are now understood to have many actions beyond their endocrine role in IGF transport. IGFBPs also function in the pericellular and intracellular compartments to regulate cell growth and survival — they interact with many proteins, in addition to their canonical ligands IGF-I and IGF-II. Intranuclear roles of IGFBPs in… 
IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications.
TLDR
An overview of IGFBP-1 in normal physiology, and its aberrantly expression and the underlying molecular mechanisms in a range of common tumors are provided, as well as the potential clinical implications of IGF BP-1 as diagnostic or prognostic biomarkers in cancer are discussed.
IGF-binding proteins.
  • L. Bach
  • Biology, Medicine
    Journal of molecular endocrinology
  • 2018
Insulin-like growth factor-binding proteins (IGFBPs) 1-6 bind IGFs but not insulin with high affinity. They were initially identified as serum carriers and passive inhibitors of IGF actions. However,
New insights on the Intrinsic, Pro-Apoptotic Effect of IGFB3 in Breast Cancer
TLDR
A signaling cascade activated by IGFBP3 is dissected, shedding new light on IGF-independent, complex effects of IGF BP3 on apoptosis and a possible role of Rho in this pathway is investigated.
What Happened to the IGF Binding Proteins?
TLDR
A more complete understanding of IGFBP biology is necessary to further define their cellular roles and determine their therapeutic potential.
Insulin-Like Growth Factor Binding Proteins in Kidney Disease
TLDR
The role of IGFBPs in regulating transcription, inducing cell migration and apoptosis is closely related to the occurrence and development of kidney disease and IGFBP-7 has been used in clinical practice as a biomarker for early diagnosis and prognosis of AKI.
Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies
TLDR
The emerging view that blocking IGF via IGFBP is a better option than blocking IGF receptors is discussed, which can lead to the development of novel cancer therapies.
IGF-Binding Protein 2 – Oncogene or Tumor Suppressor?
TLDR
The factors influencing the variation in IGFBP2 expression in cancer are discussed and the interpretation of these findings is discussed.
Epigenetic regulation of insulin-like growth factor binding protein-3 (IGFBP-3) in cancer
TLDR
This review will focus on epigenetic regulation of IGFBP-3 in cancer as IGFBP genes have consistently been identified among the most common to be aberrantly altered in tumours.
Noncoding RNA actions through IGFs and IGF binding proteins in cancer
TLDR
This review examines the functional interactions of miRNAs and lncRNAs with IGFs and their binding proteins in cancer, and reveals how the IGF axis may mediate ncRNA actions that promote or suppress cancer.
Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
TLDR
The structure and function of various IGFBPs are discussed, particularly IGF BPs as potential emerging biomarkers and therapeutic targets in various autoimmune diseases, and the possible mechanisms by which IGFBBP act on the pathogenesis of autoimmune diseases are discussed.
...
...

References

SHOWING 1-10 OF 225 REFERENCES
IGF Binding Proteins (IGFBPs) and Regulation of Breast Cancer Biology
  • C. Perks, J. Holly
  • Biology, Medicine
    Journal of Mammary Gland Biology and Neoplasia
  • 2008
TLDR
The conflicting observations between the effects of IGFBPs on the risk of breast cancer, in particular IGFBP-3, obtained from epidemiology studies in comparison to in vivo observations are highlighted and potential explanations provided.
Perspectives in mammalian IGFBP-3 biology: local vs. systemic action.
TLDR
The purpose of this review is to highlight IGFBP-3 as a novel effector molecule and not just another "binding protein" by discussing its IGF-independent actions on metabolism and cell growth.
IGF-binding proteins – the pieces are falling into place
Cellular actions of the insulin-like growth factor binding proteins.
TLDR
In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell activity in various ways and manipulation of IGFBP-regulated pathways is speculated to offer therapeutic opportunities in cancer and other diseases.
Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer.
TLDR
The finding of IGF-II and IGFBP-3 in association with unfavourable prognostic indicators of breast cancer suggests that IGFs may be involved in the progression of Breast cancer.
Unraveling insulin-like growth factor binding protein-3 actions in human disease.
TLDR
This review reinforces the concept in support of the IGF/IGF-IR axis-independent actions of IGF BP-3 and delineates potential underlying mechanisms involved and subsequent biological significance, focusing in particular on functional binding partners and the clinical significance of IGFBP-3 in the assessment of cancer risk.
Biology of insulin-like growth factor binding protein-4 and its role in cancer (review).
TLDR
The effect of altered expression of IGFBP-4 in vivo in colon and other cancers needs to be explored as locally available IGFs appear to stimulate mitogenesis.
Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities.
  • R. Baxter
  • Biology, Medicine
    American journal of physiology. Endocrinology and metabolism
  • 2000
TLDR
The regulation of cell sensitivity to inhibitory IGFBP signaling may play a role in the growth control of malignant cells.
Insulin-like growth factor-binding protein-6 and cancer.
TLDR
Understanding of the mechanisms underlying the actions of the IGF ligands, receptors and binding proteins, including IGFBP-6, will enhance the ability to develop optimal treatments that can be targeted to the most appropriate patients.
Differential impacts of insulin-like growth factor-binding protein-3 (IGFBP-3) in epithelial IGF-induced lung cancer development.
TLDR
It is shown that IGF-I, but not IGF-II, protein levels in non-small-cell lung cancer (NSCLC) were significantly higher than those in normal and hyperplastic bronchial epithelium, and that IGFBP-3, depending on its expression level, either inhibits or potentiates IGF- I actions in lung carcinogenesis.
...
...